Diagnostics for Pneumonia in Immunosuppression

Researching reliable, fast and non-invasive diagnostic tools for pneumonia pathogens and their resistance.

The Campus Project is a joint project of seven public and private partners of the InfectoGnostics Research Campus Jena and develops solutions in the form of reliable, rapid and non-invasive diagnosis of pneumonia pathogens and their resistance. The subprojects progress along the innovation chain from determining medical need and developing new technologies to preparing samples and producing prototypes. The project for the development of innovative diagnostic technologies in Jena has a total volume of EUR 14 million and is supported by the BMBF with EUR 10 million over the next five years.

At this time, pneumonia pathogens can only be diagnosed by the elaborate examination of the lungs whereby the lung is flushed in order to detect the pathogens in the rinse fluid (bronchoalveolar lavage). It is vital to replace this complex examination which is very stressful for the patient with new methods and markers. Especially for patients with weakened immune systems, timely pathogen-specific diagnosis and early and targeted therapy (antibiotic stewardship) is often lifesaving because the body's own defense mechanisms do not work.

The technological basis for this is the formation of novel concepts for the investigation of the immune response to the infection and a direct diagnosis of pathogens that is largely independent of cultivation. The collection and processing of samples such as urine, blood or samples from the lungs are processed in simplified and miniaturised devices. To determine the pathogen or the host response, new methods for duplication of the genetic material and direct light-based methods such as microscopy or spectroscopy are researched. The campus project aims to keep costs and expenses of the diagnosis low in order to bring the new methods to less developed regions or to ICUs in acute situations. As part of the research campus, new inexpensive and portable methods for point-of-care testing will be established.

Participating partners
Abbott / Alere Technologies GmbH
Analytik Jena AG
University Hospital Jena (UKJ)
Leibniz Institute of Photonic Technology (IPHT)
Leibniz Institute for Infection Biology and Natural Products Research – Hans Knöll Institute (HKI)
Friedrich Schiller University Jena
Ernst Abbe University of Applied Sciences (EAH) Jena

Duration
01.02.2015 – 31.01.2020

Project coordination
Overall coordinator: Prof. Dr. Jürgen Popp
Medical coordinator: Prof. Dr. Mathias Pletz