Stellenausschreibungen

Early Stage Researcher / PhD candidate Position JENA (Germany)

TIPAT (ESR 5): Development and validation of a clinical MBEC assay for individualization of biofilm associated infections

The Institute of Infectious Diseases and Infection Control at the Jena University Hospital (Germany) offers an Early Stage Researcher / PhD candidate position on “Development and validation of a clinical MBEC assay for individualization of biofilm associated infections (ESR 5)” as part of the Innovative Training Network (ITN) Training towards Innovative Personalized Antibiotic Therapy (TIPAT).

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Project description
Biofilms are the preferred life-form of microorganism protecting the microbes against antimicrobial treatment and the immune response and resulting in life threatening infections. In this project, biofilms of Pseudomonas aeruginosa, one of the most critical pathogens in cystic fibrosis (CF), will be addressed. The minimum concentration to eradicate a P. aeruginosa biofilm (MBEC) may be up to 1,000 times higher than the minimal inhibitory concentration (MIC) determined through routine microbiological diagnosis for planktonic bacteria. In this project, the correlation of the MBEC of the respective isolate and the patient outcome will be investigated in order to assess evidence if a personalized biofilm-diagnostic may improve the therapy in CF-patients. To do so, retrospective isolates will be investigated and the statistically correlated with patient data. Additionally, alternative CF-therapies will be tested against the isolates to proof if strain-specific variability exists. In collaboration with the Leiden University (Netherlands), the clinical and preclinical data will be used for mathematical modelling in the CF system model.

Selection criteria

  • Master degree in the field of microbiology, biology, biotechnology, or equal (graduation before project start date)
  • Experience in microbiological techniques (working under sterile condition, culturing microorganisms) are mandatory, experience in fluorescence microscopy, resistance testing and bacterial biofilms are desirable.
  • Good communication and interpersonal skills to organize research with both academics and professionals;
  • Good communication (verbal and writing) skills in English;
  • Confirmed capacity to write high-level scientific reports and papers;
  • Interested in participating in educational tasks;
  • Independent and creative team player;

Planned start of employment: Between 01-09-2020 and 01-11-2020

Duration of position: 36 months

Eligibility

  • At the time of commencing their employment, researchers must not have resided or carried out their main activity (work, studies, etc.) in the country of their (recruiting) host organization for more than 12 months in the 3 years prior to their recruitment.
  • Applicants must be in the first four years (full-time equivalent research experience) of their research career and have not been awarded a doctoral degree at the first day of their employment contract. This research experience is measured from the date when they obtain the degree which formally entitles them to embark on a doctorate (either in the country in which the degree was obtained or in the country in which the researcher is recruited), even if a doctorate was never started or envisaged. Research experience is measured to the first day of the employment contract of the researcher.
  • Usual MSCA eligibility criteria apply and will be verified during the application process. For more information on MSCA, please see: http://ec.europa.eu/mariecurieactions. Benefits

Benefits

  • The successful candidates will receive a 36-month, full-time employment contract as per Marie Skłodowska-Curie Actions (MSCA) regulations for early stage researchers. The monthly salary will be confirmed upon offer, paid in the currency of the host country, and with a correction factor applied to the host country.
  • In addition to their individual scientific projects, TIPAT ESRs will collaborate with world-leading research groups and industries within the consortium through secondments. All ESRs will benefit from further extensive and varied continuing education, completing a series of carefully designed training modules and transferable skills courses; they will participate in symposia, workshops, and international conferences and will have meaningful exposure to the industrial environment through TIPAT industrial partners.

Application procedure
Questions about this position can be send to Dr. Oliwia Makarewicz (email: oliwia.makarewicz@med.uni-jena.de).

Your application should be sent to oliwia.makarewicz@med.uni-jena.de and to applications@tipat.eu

When applying, please use the following email subject title: TIPAT ESR5 – Your Name

In your application please include the following files:

  • A motivation letter (1 page maximum), please include in your letter alternative ESR TIPAT positions of interest to you if not selected, if any.
  • A CV according to the Europass format
  • Two reference letters (at least one from your Master thesis supervisor)
  • An up-to-date of grades in your bachelor and master programs
  • Optional: English proficiency test results (TOEFL, IELTS)
  • Additional certificates documenting your skills are welcome

The application deadline is May 20, 2020. We may extend this deadline depending on the developments of the COVID19 pandemic.

The application procedure is as follows:
- A notification for receiving your application is send after the application deadline.
- Applicants are notified if they are invited for video-conferencing interviews by May 30
- Interviews are schedule to be completed by June 15
- Hiring process is completed by June 30

Please note these dates may change if the application deadline is extended.

Acknowledgement
This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No 861323.

Early Stage Researcher / PhD candidate Position JENA (Germany)

TIPAT (ESR 13): Host response biomarkers for bacterial infections using RNA profiling and Raman spectroscopy

The Institute of Infectious Diseases and Infection Control at the Jena University Hospital (Germany) offers an Early Stage Researcher / PhD candidate position on “Host response biomarkers for bacterial infections using RNA profiling and Raman spectroscopy (ESR 13)” as part of the Innovative Training Network (ITN) Training towards Innovative Personalized Antibiotic Therapy (TIPAT).

→ Apply for job via NATURE Careers

Project description
Preclinical evaluation of antibiotic efficacy is predominantly performed in non‐physiological rodent models to facilitate colonization while potential synergistic and detrimental effects of the immune response are neglected. This raises questions on the relevancy and translatability of animal models to human infection. To address this knowledge gap, on how immune factors contribute to the resolution of infection, we aim to establish well‐standardized murine models that allows following the in vivo dynamics of bacterial spread along with changes in the immune response. We will comparatively analyze infection and antibiotic therapies in immunocompetent and immunosuppressed mice, but also human and murine immune response signatures to identify molecular factors influencing the hepatic host response in life‐threatening bacterial infections. The aim is to identify immune signatures associated with early therapeutic efficacy, with the potential to allow early decision making on the appropriateness of the selected antibiotic regimen, if brought from bench‐to‐bedside.
This project will be performed in close collaboration with the Paul-Ehrlich Institute (Germany), who will establish the mouse models and provide samples, and the University of Uppsala (Sweden), who will develop mathematical models describing the interaction between immune response and bacteria, in relation to antibiotic treatment.

Selection criteria

  • Master degree in the field of microbiology, biology, biotechnology, or equal (graduation before project start date)
  • Experience in microbiological (working under sterile condition, culturing of cells lines and microorganisms) and molecular techniques (isolation of nucleic acids, PCR methods, electrophoresis) are mandatory, experience in fluorescence microscopy, resistance testing and cytology are desirable.
  • Good communication and interpersonal skills to organize research with both academics and professionals;
  • Good communication (verbal and writing) skills in English;
  • Confirmed capacity to write high-level scientific reports and papers;
  • Interested in participating in educational tasks;
  • Independent and creative team player;

Planned start of employment: Between 01-09-2020 and 01-11-2020

Duration of position: 36 months

Eligibility

  • At the time of commencing their employment, researchers must not have resided or carried out their main activity (work, studies, etc.) in the country of their (recruiting) host organization for more than 12 months in the 3 years prior to their recruitment.
  • Applicants must be in the first four years (full-time equivalent research experience) of their research career and have not been awarded a doctoral degree at the first day of their employment contract. This research experience is measured from the date when they obtain the degree which formally entitles them to embark on a doctorate (either in the country in which the degree was obtained or in the country in which the researcher is recruited), even if a doctorate was never started or envisaged. Research experience is measured to the first day of the employment contract of the researcher.
  • Usual MSCA eligibility criteria apply and will be verified during the application process. For more information on MSCA, please see: http://ec.europa.eu/mariecurieactions.

Benefits

  • The successful candidates will receive a 36-month, full-time employment contract as per Marie Skłodowska-Curie Actions (MSCA) regulations for early stage researchers. The monthly salary will be confirmed upon offer, paid in the currency of the host country, and with a correction factor applied to the host country.
  • In addition to their individual scientific projects, TIPAT ESRs will collaborate with world-leading research groups and industries within the consortium through secondments. All ESRs will benefit from further extensive and varied continuing education, completing a series of carefully designed training modules and transferable skills courses; they will participate in symposia, workshops, and international conferences and will have meaningful exposure to the industrial environment through TIPAT industrial partners.

Application procedure
Questions about this position can be send to Dr. Oliwia Makarewicz (email: oliwia.makarewicz@med.uni-jena.de).

Your application should be sent to oliwia.makarewicz@med.uni-jena.de and to applications@tipat.eu

When applying, please use the following email subject title: TIPAT ESR13 – Your Name

  • A motivation letter (1 page maximum), please include in your letter alternative ESR TIPAT positions of interest to you if not selected, if any.
  • A CV according to the Europass format
  • Two reference letters (at least one from your Master thesis supervisor)
  • An up-to-date of grades in your bachelor and master programs
  • Optional: English proficiency test results (TOEFL, IELTS)
  • Additional certificates documenting your skills are welcome

The application deadline is May 20, 2020. We may extend this deadline depending on the developments of the COVID19 pandemic.

The application procedure is as follows:
- A notification for receiving your application is send after the application deadline.
- Applicants are notified if they are invited for video-conferencing interviews by May 30
- Interviews are schedule to be completed by June 15
- Hiring process is completed by June 30

Please note these dates may change if the application deadline is extended.

Acknowledgement
This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No 861323.