Sepsis remains a race against time, driven by a complex and often maladaptive host response to infection. This symposium explores
how immune dysregulation shapes outcomes - from brain dysfunction and synaptic injury to organ failure and metabolic collapse. By
drawing insights from rare diseases, cutting-edge pathophysiology, and emerging concepts such as cellular “energy failure,” we aim to
rethink how sepsis damages the body. We are delighted to welcome Professor Mervyn Singer as our honorary lecturer, whose
pioneering work has profoundly shaped our understanding of sepsis and organ dysfunction. We are looking forward to interesting
lectures and lively discussions at this JSMM (Jena School of Molecular Medicine) Minisymposium.
Due to organizational reasons a registration is required: Registration
Program
13:00 Registration
13:25 Welcome
13:30 – 14:00 Initiation of immune responses to pathogens
Diana Dudziak, Institute of Immunology
14:00 – 14:30 Sepsis-associated encephalopathy: Maladaptive immune mechanisms in the brain lead to neuronal and synaptic damage
Ha-Yeun Chung, Department of Neurology
14:30 – 15:00 Learning about the host response to infection by studying rare diseases
Ignacio Rubio, Department of Anesthesiology and Intensive Care Medicine
15:00 – 15:30 Coffee Break
15:30 – 16:15 Sepsis and organ failure - a question of flat batteries?
Mervyn Singer, Bloomsbury Institute of Intensive Care Medicine, Division of Medicine University College London
16:15 – 16:45 Disease tolerance – A clinical perspective
Sebastian Weis, Institute of Infectious Diseases and Infection Control, Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knöll Institute (HKI), Department of Anesthesiology and Intensive Care Medicine
16:45 Concluding remarks