Partner overview

For over 20 years, -4H-JENA engineering GmbH has been an independent, expert partner in the development and production of customised measurement technology solutions. Verifiable references from numerous domestic and foreign customers are evidence of expertise and both professional and technical production requirements for implementing sophisticated solutions. The company's development is associated with consistent orientation of the production profile from the individual solution up to the system provider.

Address
Mühlenstraße 126
07745 Jena

Website
www.4h-jena.de

InfectoGnostics partner in the field
Device developers
 

Abbott Rapid Diagnostics Jena GmbH develops and manufactures novel diagnostic tests that are easy to use and can be carried out in the immediate vicinity of the patients, but also in laboratory settings. The determination of important lab values on-site enables quick and informed decisions with respect to the further course of treatment, and thus improves the quality of patient care significantly. The tests developed at the Jena site are primarily designed for patient-oriented and mobile use. The focus is on test methods to identify various infectious diseases, such as HIV and tuberculosis. Furthermore, a variety of molecular and serological tests are developed and manufactured for routine and research laboratories. After completion of the development stage, the site oversees the transfer to mass production; the products are marketed through the global sales network of the Abbott group.

Address
Orlaweg 1
07743 Jena

Contact:

www.globalpointofcare.abbott

Fon: + 49 (0) 3641 / 3111 – 0
Fax: + 49 (0) 3641 / 3111 – 120

Analytik Jena is a provider of instruments and products in the fields of analytical measuring technology, life science and optoelectronics. Their portfolio includes advanced analysis technology, complete systems for bioanalytical applications in the life science sector and optical high-end consumer products. Inter-laboratory software management and information systems (LIMS), services, and device-specific supplies and disposable material, such as reagents or plastic products, complete the extensive range of the Jena-based company.

Address
Konrad-Zuse-Straße 1
07745 Jena

Website
www.analytik-jena.de

InfectoGnostics partner in the field
Device developers

Applyo develops and produces lyophilised reagents for in-vitro diagnostics and life science research. The core product is the Lyo-Beads, spherical lyophilisates containing all the necessary enzymes and reagents for a detection reaction – ready-mixed, portioned and immediately soluble and applicable. Depending on the application, the beads can be sized in different sizes for individual reactions or produced as a concentrated master mix for many reactions. The reagents in the Lyo beads are stable for up to 3 years when stored at room temperature.

In addition to customised formulation and process optimisation for freeze-drying the reagent beads, we develop for our partners the molecular biological assays based on PCR, isothermal amplification technologies (RPA, NEAR, LAMP or NASBA) as well as immunological assays.

Address
Hans-Knöll-Str. 6
07745 Jena

Website
www.applyo-jena.com

Die AID Gruppe hat langjährige Erfahrung und Wissen in den Bereichen Diagnostika und Bildanalysegeräte und bietet diagnostische Lösungen aus erster Hand an. Darunter zählen unter anderem PCR-Nachweissysteme und Assays zur T-Zell-Diagnostik.Produkte von AID finden Anwendung im Bereich der Immunologie und Diagnostik von Infektionskrankheiten und umfassen auch automatisierbare Komplettlösungen in den Bereichen Molekularbiologie, Mikrobiologie, Virologie und Zellbiologie.

Die Autoimmun Diagnostika GmbH (AID) verantwortet den Vertrieb der Produkte aus den beiden Tochterunternehmen Genome Identification Diagnostics GmbH (GenID) und Advanced Imaging Devices GmbH. Im Forschungscampus ist derzeit vor allem die GenID GmbH an Kooperationprojekten beteiligt.

Kontakt:

Tel. +49 (0)7434 9364-0
E-mail: info@aid-diagnostika.com

www.aid-diagnostika.com

Biophotonics Diagnostics develops software solutions and database systems that help to identify life-threatening pathogens and their possible resistances quickly and easily. The combination of optical measurements and computer-based data analysis shortens the time to uniquely identify pathogens from previously at least one day to just a few hours. Phone
03641 / 206 024

Website
www.biophotonics-diagnostics.de

The biotechrabbit GmbH is focused on the production of antibodies and enzymes for diagnostic companies. The company provides hight quality, ultra pure proteins, reagents and kits for standard and custom formulations.

Services of biotechrabbit include:

• custom monoclonal antibodies and fermentation over 1 kg
• protein and enzyme production in E.coli and mammalian cell lines
• assay development
• contract research
• improvement of enzymes using rational and irrational molecular approaches
• protein expression in vitro

biotechrabbit also offers a portfolio for molecular biology reagents for researchers.

Further Information:
www.biotechrabbit.com

BLINK develops a new open product platform for in vitro diagnosis to enable partners to develop and sale own in vitro products on a common coherent technical base.Address
Winzerlaer Str. 2
07745 Jena

Germany

Website
www.blink-dx.com

Bright Giant uses profound algorithms and state-of-the-art machine learning to provide enterprise software solutions for metabolomics MS/MS analysis for research and development.

The SIRIUS software, together with CSI:FingerID and CANOPUS, greatly facilitate the structural elucidation of small molecules - such as metabolites - by tandem mass spectrometry. They are all based on cutting-edge academic research and offer outstanding performance.

The Center for Sepsis Control and Care (CSCC) at the University Hospital Jena and the Medical Faculty of the Friedrich Schiller University Jena is one of eight integrated research and treatment centres in Germany that are funded by the Federal Ministry of Education and Research. The research interests of CSCC cover all stages of the sepsis disease: from prevention and diagnosis to intensive care and rehabilitation. At the same time new structures are being created to strengthen the patient-oriented, cutting-edge research and to improve their quality and promote young scientists. Physicians and scientists at all stages of their careers are carrying out interdisciplinary work with clinics and institutes of the University Hospital Jena. In doing so, they also benefit from the close networking of the CSCC with other research institutions in Jena.

Address
Erlanger Allee 101
07747 Jena

Webseite
www.cscc.uniklinikum-jena.de

InfectoGnostics partner in the field
University
 

Curetis GmbH is a subsidiary of OpGen, Inc. an international company for precision medicine.

Curetis makes use of the possibilities of molecular diagnostics and computer science to combat infectious diseases. Together with the other OpGen subsidiary Ares Genetics GmbH and additional partners in the InfectoGnostics research campus, bioinformatics and sequencing services are used for the prediction of antibiotic resistance and further developed into molecular diagnostic on-site tests – for example in the campus project PREPLEX.

Such point-of-care solutions enable clinicians to quickly obtain easily usable information about life-threatening, multi-resistant infectious pathogens and thus to initiate effective treatment of patients at an early stage.

Contact:

Curetis GmbH
www.curetis.com

Max-Eyth-Str. 42
71088 Holzgerlingen
e-mail: contact@curetis.com

Dynamic42 GmbH was founded in the spring of 2018 in the high-tech city of Jena and is currently located at the BioInstrumentezentrum on the Beutenberg. The still young company is a spin-off of the University Hospital Jena. We develop and market novel, three-dimensional, human organ models (so-called organ-on-chip technology) for preclinical research and development as well as for testing novel pharmaceutical products, chemicals and food additives.

Dynamic42 GmbH has specialized in the area of organ-on-chip technology in the integration of the immune system, which plays a significant role in the occurence of adverse effects of drugs and has been neglected in the industry and in two-dimensional test systems. Our platform enables toxicity screenings and ADMET studies already in preclinical phases on complex microphysiological models of human organs. Hereby we accompany commercial manufacturers as well as scientists in the field of research and development in the design and execution of preclinical studies.

In addition, we develop human disease models in our chip platform both internally and with external partners – especially in areas where there are no animal models.

More information

The Ernst-Abbe-Hochschule Jena - University of Applied Sciences (founded in 1991) offers many attractive bachelor and master degree programs in engineering, business administration and the social sciences. The growing University of Applied Sciences is characterised by the following areas of focus: "Innovation for quality of life - health, precision, sustainability and networking". This includes an increasingly interdisciplinary cooperation between the university departments, whereby synergies can be optimally exploited. For this reason, teaching and research are also closely linked.

Address
Carl-Zeiss-Promenade 2
07745 Jena

Website
www.eah-jena.de

InfectoGnostics partner in the field
University

Participating in InfectoGnostics project
Pneumonia in Immunosuppression

Bringing together the excellence of virology and bioinformatics in Europe

The European Virus Bioinformatics Center (EVBC) is intended to bring together virologists and bioinformaticians across Europe and provide a platform for the implementation of interdisciplinary collaborative projects at local and transnational levels.

Website:

http://evbc.uni-jena.de/

At the heart of the Friedrich Loeffler Institute’s (FLI) work is the health and wellbeing of farm animals and the protection of humans from zoonoses, i.e. infections transmitted between animals and humans. These objectives are defined in the Animal Health Law. The FLI is working in various basic and practical disciplines.

Address
Naumburger Straße 96a
07743 Jena

Website
www.fli.bund.de

InfectoGnostics partner in the field
Non-university institution

Participating partner in the InfectoGnostics project
Chlamys

FluIDect brings advanced pathogen analysis in pocket-sized instruments directly to the production site, enabling seamless process monitoring and control.

Today's bioanalytical methods are limited to physically remote laboratories. FluIDect's sensing technology uses light-emitting µBeads as messengers to measure pathogens in liquid products along the entire process chain in real time. They work in vitro and in vivo and can be adapted to specific targets.

Website:
http://fluidect.com/

The Fraunhofer Institute for Ceramic Technologies and Systems IKTS, with its three sites in Dresden and Hermsdorf (Thuringia), covers the field of high-performance ceramic from the basic initial research to the application in its entirety.  The range of services comprises the application-focussed development of ceramic high-performance material, industry-related powder-technological manufacturing methods and prototypal parts. The diagnostic material branch of the institute, proceeded in January 2014 by the Dresden site of the Fraunhofer Institute for Non-destructive Testing, extended the research portfolio to the topics of material diagnoses and exams.

In addition, in the field of functionalisable bioceramics for bridges, crowns, dental and endoprothetic implants respectively, the bioinerten and biocompatable combined systems also suit specifically therapeutic and diagnostic acutators as well as Multi-Sensor arrays for stimulative, suppressive and monitoring purposes, focussing on extensive research activities.

Functional, adjustable ceramic nanofiltration membranes developed and produced at Fraunhofer IKTS are used in diagnostic and detectable micro-systems.  It is already used in the development of biophysical and biochemical separation models for sample preparation and enhancement of sample components (cells, bacteria, protein, toxins, etc.).

Address
Fraunhofer Institute for Ceramic Technologies and Systems IKTS
Michael-Farady-Straße 1
07629 Hermsdorf

Website
www.ikts.fraunhofer.de

InfectoGnostics partners in the field
Non-university institution

Participating partner in the InfectoGnostics project
ROWdix
 

Friedrich Schiller University Jena is Thuringia’s only comprehensive university. Founded in 1558, today the university offers almost 200 majors and subjects, ranging from archaeology to dentistry. Roughly 18,000 students (Summer Semester 2014), of whom over 1,900 are international, are enrolled at University of Jena and their university’s consistently good conditions of study are being evidenced in various different rankings and studies.

University of Jena distinguishes itself through high research dynamics. Traditionally the university maintains an interdisciplinary invested working style as well as a network with non-university research institutes and the economy. The research has for many years been systematically reoriented and is focussed on five priority areas:

• Optics, photonics and photonic technologies
• Innovative materials and technologies
• Dynamics of complex biological systems
• Laboratory enlightenment
• People in processes of social changes

 Above all the scientific trainees at University of Jena are supported. With its Graduate Academy, recognised throughout Germany for its exemplary work, the university focusses on optimal qualification and highest quality standards The 120-plus cooperation agreements University of Jena has with universities all over the world highlight the international focus of the university.

Address
Fürstengraben 1
07743 Jena

Website
www.uni-jena.de

InfectoGnostics partner in the field
University

Participating partner in InfectoGnostics projects
Pneumonia in Immunosuppression

FastTB  

Since 1994 the Research Centre for Medical Engineering and Bio Technology has been active as a charitable, economy-orientated research institute with emphasis on medical technology, veterinary research and development work. 100 highly-qualified and engaging experts work in fzmb GmbH in modern and equipped laboratories towards the development of innovative products and services and offer market-orientated complete solutions for customers and small and medium-sized enterprises. As an initiator and a member of different national and international networks, the institute understands that it is an important link between industry and research.

Address
Geranienweg 7
99947 Bad Langensalza

Website
www.fzmb.de

InfectoGnostics partners in the field
non-university institution (industry-orientated research institution)
 

Als Tochterunternehmen der AID Autoimmun Diagnostika GmbH in Straßberg (Baden-Württemberg) entwickelt und produziert In-Vitro Diagnostika, die u.a. für den Nachweis funktionaler T-Zellen genutzt werden können und sich als universelle Plattform für den Einsatz mit verschiedenen verfügbaren Antigenen und unterschiedlichen Fragestellungen eignet. Im InfectoGnostics Forschungscampus beteiligt sich GenID an einem gemeinsamen ZIM-Projekt mit der Uniklinik, das sich der Entwicklung eines Multiplex-Ansatzes zur Detektion von Antibiotikaresistenzen in gram-negativen Bakterien widmet.  Im Fokus steht dabei der Nachweis von einzelnen phänotyp-bestimmenden Substitutionen‘.

Weitere Informationen und Kontakt

The "Institut für Bioprozess- und Analysenmesstechnik e.V." (iba) is a non-university research institute of the Free State of Thuringia and an affiliated institute of the TU Ilmenau. The iba employs around 60 people from a wide range of disciplines (biology, biochemistry, physics, chemistry, engineering) and its main focus is on application-oriented research.

With its interdisciplinary focus, iba covers a broad spectrum in the life sciences and translates findings from basic research into applications - for example, from biology into biotechnology and medical technology. In this application-oriented research, the institute benefits from decades of experience in the field of technical systems as well as the investigation and use of biological functions in these systems and its interfaces. On this basis, iba researchers are cooperating with partners from university, independent research institutes and industry.

Further information: https://www.iba-heiligenstadt.de

Jenoptik uses the potential of light not only to give its customers a step ahead in global markets but also to help shaping changes in society.

As a globally operating technology group the company has been active since January 2019 in the three photonics based divisions Light & Optics, Light & Production and Light & Safety.

The company's Light & Optics division actively contributes within the InfectoGnostics Research Campus with  R&E activities that cover optics, laser technology, digital image processing, optoelectronics and sensor technology. In the field of biophotonics, the division focuses on applications for bio-imaging and laser-based therapies. Jenoptik is a leader in the development of OEM solutions and products for the medical technology / life science sector and also develops innovative configurable technology platforms for digital image processing and analysis.

Jenoptik's headquarters are in Jena (Thuringia). In addition to several major sites in Germany, Jenoptik is present in over 80 countries worldwide, for example with production and assembly sites in the USA, France, Great Britain, China and Switzerland. The group is also represented by subsidiaries in Australia, Brazil, India, Japan, Malaysia, Mexico, the Netherlands, Singapore, South Korea and the Czech Republic. Jenoptik employs over 4,000 people and in the 2019 fiscal year achieved sales of around 855 million Euros.

Contact:
Carl-Zeiß-Straße 1
07743 Jena, Germany
Phone: +49 3641 65-0
Email: pr@jenoptik.com

www.jenoptik.com

Natural product mediators of biological communication are essential for life. They are involved in the formation of many infectious diseases and are amongst the most important sources for clinical drugs, in particular antibiotics. At the Hans Knöll Institute, Natural Product Research and Infection Biology are closely linked. The scientists at the HKI want to elucidate how microorganisms produce, on the one hand, virulence factors, and on the other, pharmacologically relevant substances. They are interested in the communication between microorganisms such as bacteria and fungi, but also the interaction of pathogenic microorganisms - especially of fungi - with their host. New natural products from microorganisms are tested for their efficacy against infections; these results are used to chemically modify the natural products in a directed manner. Furthermore, strategies used by microorganisms to overcome the immune system will be investigated. These studies lay the groundwork for the future development of new diagnostics and intervention strategies, which are required urgently to fight soaring fungal infections and antibiotic resistance. This application-orientated fundamental research will advance the development of new natural product-based treatments.

Address
Beutenbergstraße 11a
07745 Jena

Website
www.leibniz-hki.de

IG partner in the field
Non-university institution

Participating partner in the InfectoGnostics project
Pneumonia in Immunosuppression




 

The Leibniz Institut of Photonic Technology researches the scientific basics of photonic processes and systems of the highest sensitivity, efficiency, and resolution. In keeping with its “Photonics for Life” motto, IPHT develops custom solutions to problems in the fields of medicine and the life and environmental sciences that are based on this research. Following IPHT’s principle “From Ideas to Instruments,” we implement the insights gained from our research into processes, instrumental concepts, and sometimes even into laboratory prototypes in order to sustainably contribute to the benefit of patients and consumers.

Adresse
Albert-Einstein-Straße 9
07745 Jena

Website
www.ipht-jena.de

InfectoGnostics partner in the field
non-university institution

Participating partner in InfectoGnostics projects
Pneumonia in Immunosuppression
OptoMon
FastTB
ROWdix

 

Nanozoo offers services for sequence-based questions. For this, the team provides end-to-end analyses to automate the data-intensive biology from sample to report for the customer. Instead of cultures and microscopes, the start-up relies on data and code to provide better insight into the microbial world. To do this, it uses established algorithms, but also develops its own methods for bioinformatics analysis based on artificial intelligence. Nanozoo also specialises in curating extensive databases of microbial genomes and their phenotypes, comprising hundreds of thousands of data sets.

Nanozoo offers the following services:

• Genome reconstruction of pathogens
• Outbreak tracking
• Metagenome and microbiome analyses
• Biomarker design
• RNA analyses

However, data and programme code are only valuable if one knows how to obtain comprehensive and reproducible results from them. The company therefore also offers targeted expert advice for a wide range of pathogen types (bacteria, archaea, fungi, protists and viruses).

Contact:
nanozoo GmbH
c/o InfectoGnostics Forschungscampus Jena
Philosophenweg 7
07743 Jena
nanozoo.org

Navimatix GmbH from Jena stands for innovative software development. In the constant search for sustainable solutions, the company always brings the latest technologies on the way to meet individual user requirements. Navimatix is characterized by a particular strength in the development, maintenance and support of distributed, scalable and highly available software solutions.
Current technologies and processes such as IoT infrastructures, cloud computing, mobile applications, microservices, DevOps and agile software development are the focus of the company's daily work. The entire company portfolio also includes many other technologies, ranging from server-based information systems to hardware-based sensor network applications. With the help of these technologies, Navimatix realizes a wide range of projects for different industries.

Address
Tatzendpromenade 2
07745 Jena

Website
https://www.navimatix.de/

NEMIS Technologies AG is a diagnostic company transforming microbiological detection in the fields of food safety, clinical diagnostics, water safety, and animal health. We empower users to minimize microbiological risk by providing a unique lab-free detection system that is simple to use.

Contact:
nemistech.com

On the basis of patented epignetic markers, oncgnostics is developing highly reliable molecularbiological tests for early diagnosis, therapeutic decisions and aftercare in cancer diagnosis.Problem

• Many cancers are still being discovered too late through a lack of unified markers and tests.
• In the early diagnosis of cervical cancer the cytologic Pap-test on swabs is still the most common method ( 17m tests p.a.). Since its value depends strongly on subjective factors, over half of all women with diseases will be overlooked.
• Tests on the cervical cancer-triggering papillomia virus (HPV) will mostly only be used in the clarification of more conspicuous Pap-smears. (0.8m tests p.a.) Their negative predictive value is high - women who are not contagious have no ailments. But: clinically relevant preliminary stages, or even cervical cancer, are only present in 10-15% of all HPV-positive women. Therefore a test system with a clear result for cancer as well as with correlated preliminary stages is urgently needed.

Solution

• Epigenetic, based on DNA methylation molecular markers. DNA methylation constitutes a natural DNA chemical modification, which can cause mutation of genes, for example. Tumour tissue indicates specific DNA methylation partners are available for diagnosis.
• oncgnostics has validated a set of markers for cervical cancer by means of best characterised, clinically relevant patient material. The subsequent test, GynTect® provides a reliable assessment, which requires invasive diagnosis and treatment for HPV-infected women.

Address
BioInstrumentezentrum Jena
Winzerlaer Straße 2
07745 Jena

Website
www.oncgnostics.com

InfectoGnostics partner in the field
Small and medium-sized enterprises
 

QInstruments develops scientific laboratory instruments for the automation of mixing processes. The company is the world's leading supplier of highly automatable shakers and thermal mixers for daily diagnostics. Innovations under the "BioShake" label define a new standard in miniaturization, precision and speed.

Global customers include life science research laboratories, universities, medical centers and laboratories in the pharmaceutical and biotechnology industries. To reach different markets, QInstruments enters into strategic alliances with partners who have excellent and established marketing and sales strategies.

QInstruments is supporting the InfectoGnostics Research Campus Jena as a sponsoring member.

Address
Loebstedter Str. 101
07749 Jena
Germany

Website
www.QInstruments.com

Senova is an internationally active company which has specialised in premium immunological rapid tests for sensitive evidence of protein, haptens, nucleic acid, microorganisms and viruses. In addition the optimisation of ELISA procedures above all the development of strip tests. Strip tests, or also Lateral Flow Assays (LFA), are the classics after rapid tests and are consolidated as a result of their simple application and short analysis times particularly for POC applications.

Address
Industriestraße 8
99423 Weimar

Website
www.senova.de

InfectoGnostics partner in the field
Non-university institution (KMU)

SmartDyeLivery develops and commercialises a patent-pending unique technology platform for the cell-type- and tissue-specific delivery of active pharmaceutical ingredients (API) on the basis of functionalised nanoparticles. Due to its targeted delivery and controlled release in the target tissue this universal platform technology enables a systemic administration of highly potent API’s. Thus, also reduced dosages leading to sufficient tissue levels.
This approach has the potential to significantly improve the spectrum of side effects of administered API’s. The unique strategy of functionalisation of nanoparticles with dyes also enables a combined approach of therapy and diagnostics in a so called theranostic concept.

As first core application the team of SmartDyeLivery focusses on the clinical picture of septic cholestasis, a sepsis based organ dysfunction of the liver associated with a very high mortality rate.

Beside this first core application and based on the modular principle of the SmartDyeLivery-technology, it can be also used for additional fields of applications. Functionalisation with different molecules enables specific targeting of various tissues, different cargos allow approaches in additional therapeutic areas. Moreover, the polymer-based nanoparticles can be adapted in size and release kinetics to the specific question.

Address
SmartDyeLivery GmbH
Botzstraße 5
07743 Jena

Website
www.smartdyelivery.de

InfectoGnostics partner in the field
Non-university institution

Jena University Hospital is the only university medicine location in Thuringia with a history of over 200 years. The tradition of medical teaching and research is even older still - as one of the founding faculties of University of Jena the medical faculty can look back on over 450 years of experience.

Today the university hospital is the biggest in the region, with over 4,800 members of staff. In the 27 clinics and polyclinics there are 1,400 beds which are used to treat 425,000 in and out patients annually.  With offers of high-end medicine, such as the transplantation centre, perinatal centre, interdisciplinary breast centre and the university tumour centre ensures that the Jena University Hospital has the maximum care for the region and far beyond. It is also a basic and standard care hospital for the city of Jena and the vicinity.

2,300 students of human, dental and molecular medicine are enrolled in the medical faculty. Scientists work not only in patient-specific clinical research but also in biomedical fundamental research at the 25 institutes and the University Hospital research groups.

Address
Bachstraße 18
07743 Jena

Website
www.uniklinikum-jena.de

InfectoGnostics partner in the field
University

Participating partner in InfectoGnostics projects
OptoMon
Chlamys
Pneumonia in Immunosuppression