NEXD explores the diagnostic use of cell-free DNA (cfDNA) in hard-to-diagnose infections such as infective endocarditis and invasive pulmonary aspergillosis. Using nanoreactor beads from BLINK AG, nucleic acids are extracted from large sample volumes and detected via digital multiplex PCR. The method enables bias-free sequencing and microbiome analysis from plasma, urine and swabs. AI-supported software simplifies data interpretation and reduces costs, enabling faster, hypothesis-free pathogen detection.