In the host organism (humans and livestock), bacterial infections result in causal chains that determine the course of the disease, can lead to secondary diseases and accordingly have great significance for the health of the population and the economy. These causal chains are still not fully understood today. In addition, there is often a lack of affordable and viable screening tests that can detect diseases at an early stage, particularly in animal husbandry.
Using the example of acute respiratory infectious disease with Chlamydia psittaci (Cp) in calves, blood will be searched for typical reaction patterns at the protein level. It is expected that the signatures determined in this way contain parameters that are both useful for early diagnosis and help to better explain the expected progression and the pathological mechanism of this serious infectious disease and thus form a basis for improved prevention or intervention.
At the same time, the previously created Omics research platform will be significantly expanded in order to achieve the required degree of automation and throughput, the required proteome coverage and the precision required for screening efforts. Regional skills will be combined with this as well.
- The Proteomics Facility Unit at UKJ (University Hospital Jena, Biochemistry Institute I) established in the funding project HighOmics1 will explore search methods, map proteomes and make comparisons.An established and well-standardised large animal model with high economic importance will be used for research into the proteome-based search for biomarker signatures in acute infectious diseases. The samples for this will be provided by the Friedrich Loeffler Institute, Institute for Molecular Pathogenesis, Jena.
- The software solution to support the biomarker search developed by X-CASE GmbH, Ilmenau, in the HighOmics1 funding project will be significantly expanded and effectively used for research.
- The research platform created by CyBio AG, Jena, in the HighOmics1 funding project will be significantly expanded and thus more effectively used for research.
Participating partners
University Hospital Jena
X-CASE GmbH
CyBio
Friedrich Loeffler Institute
Duration
01.10.2013 - 31.03.2015
Project coordination
CyBio
The project funded by the Free State of Thuringia was co-financed by European Union funds under the European Regional Development Fund (ERDF).